Andrea Bocelli health: How did the star go blind? Singer’s condition explained

Andrea Bocelli, 61, who is currently embarking on a worldwide tour, was diagnosed with glaucoma following a football accident, and by the age of 12 became completely blind. Born to Alessandro and Edi Bocelli, doctors advised the couple to abort Andrea, as they predicted he would be born with a disability.

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It became evident at birth that the singer had numerous problems with his sight, and was eventually diagnosed with congenital glaucoma.

At the age of 12, Andrea lost his sight completely after an accident during a football game.

He was hit in the eye playing the position of goalkeeper during a match, and as a result, suffered a brain haemorrhage.

Doctors used leeches in a last effort to try and save his sight, but they were unsuccessful and Andrea remained blind.

So what is glaucoma?

Glaucoma is a common eye condition where the optic nerve, which connects the eye to the brain, becomes damaged.

The NHS explains: “It’s usually caused by fluid building up in the front part of the eye, which increases pressure inside the eye.

“Glaucoma can lead to loss of vision if it’s not diagnosed and treated early.

“It can affect people of all ages, but is most common in adults in their 70s and 80s.”

Symptoms of glaucoma

The health body says glaucoma doesn’t usually cause any symptoms to begin with, and tends to develop slowly over many years.

For this reason, many people don’t realised they have the condition, and it may only be picked up during a routine eye test.

If symptoms do arise they may include blurred vision or seeing rainbow-coloured circles around bright lights.

The NHS continues: “Both eyes are usually affected, although it may be worse in one eye.”

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Occasionally, glaucoma can develop suddenly and cause:

  • Intense eye pain
  • Nausea and vomiting
  • A red eye
  • headache
  • Tenderness around the eyes
  • Seeing rings around lights
  • Blurred vision

Causes of glaucoma

Nerve damage in the eye is usually related to increased pressure in the eye.

Mayo Clinic advises: “Elevated eye pressure is due to a buildup of a fluid (aqueous humor) that flows throughout the inside of your eye. This internal fluid normally drains out through a tissue called the trabecular meshwork at the angle where the iris and cornea meet.

“When fluid is overproduced or the drainage system doesn’t work properly, the fluid can’t flow out at its normal rate and eye pressure increases.

“Glaucoma tends to run in families. In some people, scientists have identified genes related to high eye pressure and optic nerve damage.”

How to prevent glaucoma

Mayo Clinic recommends some self-care steps to help people detect glaucoma in its early stages.

It advises:

  • Get regular dilated eye examinations
  • Know your family’s eye health history
  • Exercise safely – regular, moderate exercise may help prevent glaucoma by reducing eye pressure
  • Take prescribed eyedrops regularly
  • Wear eye protection when using power tools or playing high-speed racket sports in enclosed courts.

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Rebecca Adlington health: Olympian reveals ‘unsettling’ health battle – key symptoms

Rebecca Arlington may have retired from all competitive swimming at the age of 23, but she has left behind a formidable sporting legacy.

One of her most notable achievements include being crowned the first British swimmer to win two Olympic gold medals since 1908.

The olympian’s fiercely competitive streak may give off the impression that nothing phases her but she has struggled with her own personal trials too.

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Speaking to the Daily Mirror, the swimmer revealed she needed months of therapy to beat panic attacks sparked by her fear of “death and the unknown”.

Rebecca recalled how the traumatic experience would affect her week in week out over summer.

And despite having a robust support network of friends and family, Rebecca struggled to open up.

According to Bupa, a panic attack is a period of severe fear and overwhelming physical feelings.

Around one in every three people experience panic attacks in their lifetime.

Panic attacks can either occur unexpectedly or be triggered by a particular situation, notes Bupa.

“They may happen to you just once, or repeatedly over time. While they are unlikely to cause any lasting physical harm, experiencing panic attacks can be very distressing,” the health body added.

How can I tell if I am having a panic attack?

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According to the NHS, if you experience sudden, intense anxiety and fear, it might be the symptoms of a panic attack.

Other symptoms may include:

  • Feeling that you’re losing control
  • Sweating, trembling or shaking
  • Shortness of breath or breathing very quickly
  • Feeling sick (nausea)

As the health site explains a panic attack usually lasts five to 30 minutes. They can be very frightening, but they’re not dangerous and should not harm you.

How to treat it

Treatment may consist of talking therapies or counselling – coping strategies that proved effective for Rebecca.

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She said: “It’s been life-changing, not just because of the therapy but talking about it a lot more. I haven’t really told anyone.”

Sharing experiences with her friends and family also helped the swimmer confront the mental health issue too.

The athlete revealed: “Loads of my friends and family members have all suffered from mental health problems over the last 10 years, so it’s not something that is hush-hush in our family anyway.

“And I know from my family’s experience every single one of us has a different trigger which brings on panic attacks.”

According to Bupa, there are a number of self-help tips people can follow to help combat panic attacks.

Exercise, for example, can help alleviate the issue, as the health body explained: “Exercise triggers the release of a set of ‘happy’ hormones known as endorphins which have been shown to improve mood and reduce anxiety.”

Other aspects of a healthy lifestyle, including eating a healthy diet, and avoiding stimulants such as caffeine, alcohol and nicotine, as well as getting a good night’s sleep, could also help, says the health site.

In addition, breathing and relaxation techniques such as yoga and Tai chi may also the trick by relaxing the mind and body.

Bupa added: “This can reduce stress and anxiety which could prevent the occurrence of a panic attack.”

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My day on a plate: Todd McKenney

Entertainer Todd McKenney, 54, shares his day on a plate.

Todd McKenney.

6am I’m up bright and early and start the day with a glass of water and a latte.
6.30am I tuck into a bowl of yoghurt, blueberries, strawberries and muesli.
9.30am A small latte.
12pm I’m on the run between rehearsals and a TV shoot, so I grab a chicken and couscous salad and have a big drink of water.
3.30pm On the way home, I snack on an apple and some almonds.
5.30pm After my workout, more water.
7pm I cook a beef stir-fry with vegetables and brown rice, accompanied by a glass of red wine.
9pm I have a cup of tea and a couple of squares of dark chocolate.

Dr Joanna McMillan says …

Top marks for … A pretty gold-star day. Your muesli and brown rice delivered wholegrains – brilliant for gut health – you got your daily recommendation of two pieces of fruit with the berries and apple. You ate the recommended daily handful of nuts and enjoyed an antioxidant-rich treat in the form of the dark chocolate.

If you keep eating like this you’ll … Be singing and dancing well into your twilight years! Good nutrition is essential to support our physical and mental health as we age and days like this put you well on track.

Why don’t you try … Including an oily fish such as trout, salmon or sardines twice a week to boost your long-chain omega-3 fats, which are essential for brain health. At least once a week enjoy a vegetarian meal incorporating beans, chickpeas or lentils to boost your plant food intake and variety.

Todd McKenney will perform in Sydney on December 21 at Woolworths Carols in the Domain, which will be broadcast on Channel 7.

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'I'm an endurance runner with one kneecap – don't tell me vegans are weak'

Fiona Oakes is an extreme endurance runner. She has broken four Guinness World Records and runs in some of the world’s most inhospitable climates, including the polar ice caps and volcanic rings.

Fiona has achieved all of this with a disability. She lost a kneecap in an injury when she was 17 and doctors told her she would never walk again, let alone run. Despite this – it’s her vegan diet that causes people to question her ability.

‘I have been vegan far longer than I have been a runner,’ Fiona tells Metro.co.uk. ‘I actually became vegan when I was six years old, and I have honestly never found my veganism too difficult or compromising to any aspect of my life.

‘I think the biggest misconception people have about veganism is that it isn’t healthy – but I’m testament to the fact it is.

‘I’ve broken four Guinness World Records for running, having been vegan for 47 years now, and I’m very healthy.

‘I built my athletic strength on a plant-based diet, and all this despite my permanent disability.’

Fiona has faced skepticism and disbelief throughout her running career when it comes to her dietary choices. She thinks it’s vital to change perceptions about what people can achieve on a vegan diet.

‘When I ran the Marathon des Sables in 2017, I took a film crew with me who were making a documentary about my life – Running for Good.

‘The director asked the guys I was sharing my tent with; “what do you think about Fiona?” And one answer was; “she’s not what I expected a vegan to be like.”

‘Remember, this is almost three years ago, before the meteoric rise of vegan and plant-based living, but I can only assume he didn’t expect a vegan woman to be out in the Sahara Desert, running the toughest footrace on the planet for the third time.

‘After decades of veganism, my goal when I started running was to break down the myths and stereotypes attached to it at that time, in that it was some way deficient, hardly adequate and prohibitive to doing anything more than sedentary activity.’

Fiona says that one of the toughest moments of her career was the first time she competed in Marathon des Sables in 2012.

Having decided to move up in distance from road running, Fiona was going to be the first vegan woman to tackle the race – and there was quite a buzz about it online.

The event itself is unbelievably gruelling. It’s a week-long, self-sufficiency, multi-stage race across the Sahara Desert, where temperatures can exceed 50 degrees and the terrain is extremely hostile.

If any sand gets into your shoes it can cause ferocious blistering.

‘I have actually known of people’s feet becoming so blistered that they needed skin grafts,’ says Fiona.

What made this first epic race so incredibly difficult, was that one week before the starting gun, one of the elderly horses – from the animal sanctuary Fiona started in the 90s – had stood on her foot, fractures two toes and caused horrendous swelling.

‘I won’t go into detail but by 82km, I could actually see the bone sticking out of my little toe,’ Fiona remembers.

‘My foot was absolutely smashed to a pulp but I managed to keep going and keep strong enough to complete the race. I proves that anything is possible if you want it badly enough.’

Running non-stop, for hours at a time – through punishing conditions – seems unimaginable for most of us. Fiona says the real struggle is often mental rather than physical.

‘Ultramarathons are a state of mind rather than body for me,’ she explains. ‘Because I come from an elite road running background I am used to running quite high weekly mileage – around 160km – so I have the physical base fitness to carry me through, but the mental side of things in ultras is what is different.

‘You have to manage your body and your mind carefully and always try to look for the positives rather than focussing on the negatives – which can quickly seem overwhelming if you dwell on them.’

She says the intense, multi-stage races take her to some ‘pretty dark places’, and often she has to really battle to keep her demons in check.

‘You are out there, day-in day-out, on your feet for hours, really pushing through the pain. However, the long-term benefits far outweigh the short-term inconveniences, pain and struggles.

‘They teach you so much about yourself and, strangely enough, even though you literally have nothing apart from what you carry on your back, you have everything because you have the freedom and the ability to be there.

‘When you return to your day-to-day life, even the most seemingly trivial events – like turning on a tap and fresh, drinkable water miraculously appearing – is something to behold and cherish.’

Fiona says running enriches every element of her life, and she is deeply grateful for everything it brings her.

‘I love the freedom of being out in the wilderness and the new and exciting experiences and adventures running always uncovers,’ she explains.

She adds that it isn’t difficult adapting a vegan diet to enable her to achieve such physical extremes – it’s just about working out exactly what your body needs.

‘Like any other diet, the main thing is that you find the correct nutritional balance for your particular lifestyle,’ says Fiona.

‘Mine has always been very active. I used to cycle 30 miles each way in to London to work, and now spend any time I’m not running caring for our 550 rescued animals at the animal sanctuary I founded 25 years ago.

‘I don’t fixate over my diet, but I have learned over the years to listen to what my body is telling me and act accordingly.

‘I don’t think there is one set eating plan which suits all as everyone’s needs are different – but basically I adhere to a whole grain diet including plenty of fresh, seasonal, locally sourced vegetables and fruits.’

Fiona says that her convinction in her beliefs is what makes her a strong woman.

‘For the animals, the planet, other human beings, personal health and the future, my veganism is at the core of all I do.

‘It encapsulates justice and compassion for all – something I have always been passionate about.’

Strong Women

Strong Women is a weekly series that champions diversity in the world of sport and fitness.

A Sport England study found that 40% of women were avoiding physical activity due to a fear of judgement.

But, contrary to the limited images we so often see, women of any age, size, race or ability can be active and enjoy sport and fitness.

We hope that by normalising diverse depictions of women who are fit, strong and love their bodies, we will empower all women to shed their self-consciousness when it comes to getting active.

Each week we talk to women who are redefining what it means to be strong and achieving incredible things.

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Meghan King Edmonds Reunites with Her Kids as She Sets Up New Home in California Amid Divorce

Meghan King Edmonds has been reunited with her babies!

On Thursday, the former Real Housewives of Orange County star, 35, revealed on her Instagram Stories that she was heading to the airport to pick up her daughter Aspen, 3, and 1-year-old twin sons Hart and Hayes, whom she shares with estranged husband Jim Edmonds.

Meghan had been apart from her kids while she worked to get her Los Angeles, California home ready for their arrival. During that time, Aspen, Hart and Hayes stayed with Jim, 49, in St. Louis, Missouri. Jim previously revealed that he had moved into his and Meghan’s newly completed mansion by himself amid their divorce.

“I cannot wait to see my kids. I am on my way to get them from the airport, and I think the house is finally ready,” Meghan said in the video, which has since expired, panning the camera to show her new home.

“I got all my IKEA stuff ready to go,” Meghan continued, showing off the sleek new furniture as well as a children’s table and a play area for her kids, which includes an art easel.

“Going to go get those babies!” Meghan added.



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Meghan then shared that her mom and sister flew with her kids to California. She later posted a hilarious text message from her sister, who said, “I feel like running a marathon would be less exhausting lol,” when asked how the plane ride was.

Moments later, Meghan posted another video, this time from the airport, of her and her kids waiting for their luggage at baggage claim.

Aspen was certainly excited to see her mom as she repeatedly yelled out, “Mom, mom!”

After some time, Meghan was able to successfully get the kids, her mom and sister and their bags out of the airport.

“Hot mess,” Meghan said in a different video as she left the airport. Her children can be heard crying and screaming in the background.

“It takes a village,” Meghan said, adding, “I feel really bad. I think it was a rough flight.”

Finally, the kids made it home and settled down for a nap — that is of course after playing with their toys at Meghan’s new place.

“That’s SILENCE Folks! The terrorists left a lot of evidence but it’s worth this sound,” Meghan wrote over a clip showing the floor of her house covered in toys.

Before touching down in Los Angeles, Jim shared a photo with the tiny tots, sharing that they were off to see mommy.

“The littles are getting big. Headed to Cali to see mommy and get Hart a little bit more treatment,” Jim wrote. Hart has sought treatment in California after being diagnosed with “irreversible brain damage” earlier this year.

Meghan revealed on her Instagram Stories earlier this week that she had moved into a “long term” rental and was getting it ready for her three toddlers.

On November 8, just two weeks after reportedly filing for divorce from Meghan following his sexting affairs and amid rumors that he had an affair with their former nanny, Carly Wilson, Jim revealed that he was moving into the St. Louis home. The property had been under construction for two years.

Both Jim and Wilson denied having a sexual relationship.

The pair had been showing off the progress on their “dream” home earlier this year, prior to their marital problems. Meghan shared several before-and-after photos of the enormous space, including one of her “dream closet.”

Despite the circumstances, Jim and Meghan are reportedly committed to co-parenting their children, according to Bravo. The former couple have agreed to joint custody of their kids.

Jim and Meghan split in October after five years of marriage.


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Over 7,600 People Trust This $7 Foot Cream to Tackle Dry Cracked Feet All Winter Long

While your feet are likely the furthest thing from your mind (both figuratively and literally) when developing a winter skincare routine, they’re still prone to the negative effects of cold weather like flaking, cracking, dryness, and redness.

With the worst of winter yet to come, it’s time to take proactive measures and upgrade your foot care routine now. Luckily, Amazon shoppers have already uncovered the best option for healthier feet: O'Keeffe's for Healthy Feet Foot Cream ($7; amazon.com). 

The number one best-selling foot cream on Amazon, it has over 7,600 positive reviews from reviewers deeming it an affordable solution for irritated, cracked feet. The concentrated foot cream works by creating a barrier along your feet that simultaneously rehydrates the skin and locks in moisture long-term. 

The star ingredient that separates O’Keeffe’s formula from other foot creams is the high concentration of allantoin. The non-toxic extract of uric acid is known for its healing, soothing, and anti-irritating properties. It not only helps promote healthier skin, but can also speed up the healing process of skin that’s already damaged, according to the U.S. National Library of Medicine.  

okeefes-healthy-feet moisturize feet skin

To buy: O'Keeffe's for Healthy Feet Foot Cream, $7; amazon.com

Not only will your dry, cracked feet instantly feel better post-application, but with time they’ll look way better, too. The Amazon listing for the fragrance-free cream includes a number of intense transformation photos that capture the evolution of dry, cracked heels into smooth soft baby feet. 

foot-cracked-heel

Even if a picture is worth a thousand words, the tried-and-true product also has plenty of powerful written testimonials from reviewers who swear it completely saved their feet. Not only did many people call it the best foot cream on the market, but over 90 percent of the reviews are positive and consist of customers raving about how well it works. 

“I wouldn't blame you if you threw up a little looking at the before and after pics. I'm 30 years old and thought to myself ‘my good feet days are in the past,’” wrote one reviewer. “I tried EVERY lotion, special Dr. Prescription moisturizing lotion, even at home foot scrubs and soaks, overnight foot wraps. NOTHING WORKED! My heels were so badly cracked it hurt to walk. Nothing works as good, and as FAST AS this lotion. No more being shy, embarrassed how my feet look.”

When applied daily—ideally to exfoliated skin post-shower or right before bedtime—a 3-ounce jar of the heavy-duty foot cream should last a little over a month. While a single canister goes for just $7, you can save even more on a bulk order with a 3-pack of O’Keeffe’s cream for just $20 and a 12-pack for $60. Either way, your feet will finally get the TLC they deserve.

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In surprise decision, US approves muscular dystrophy drug

U.S. health regulators approved a second drug for a debilitating form of muscular dystrophy, a surprise decision after the medication was rejected for safety concerns just four months ago.

The ruling marks the second time the Food and Drug Administration has granted preliminary approval for the disease based on early results and is likely to stoke questions about its standards for clearing largely unproven medications.

The FDA said late Thursday it approved Sarepta Therapeutics’ Vyondys 53 for patients with a form of Duchenne’s muscular dystrophy. Duchenne’s affects about 1 in every 3,600 boys in the U.S., causing muscle weakness, loss of movement and early death, usually when patients are in their 20s or 30s. The drug is for a specific type that affects about 8 percent of boys with Duchenne’s.

In August, the FDA appeared to reject the injectable medication, sending a letter to the company flagging risks of infections and kidney injury. But Sarepta disputed the decision, raising it to FDA’s drug center leadership. The company resubmitted its application and data, and the FDA reversed its decision, according to a Sarepta press release.

The surprise announcement sent company shares rocketing more than 36% in trading Friday. But some Wall Street analysts said the approval suggests loosening standards at the agency.

“The abruptness of the decision making at the agency does not inspire confidence, in our view,” analyst Debjit Chattopadhyay wrote in a note to investors.

It’s the second time a Sarepta drug has followed an unusual path to approval. In 2016, FDA leaders cleared the company’s first muscular dystrophy drug, overruling agency reviewers who said there was little evidence it worked. The decision also followed an intense lobbying campaign by patients’ families, politicians and physicians. Agency critics suggested the FDA may have bowed to outside pressure.

Vyondys received “accelerated approval” based on preliminary results showing it boosts a protein that aids the growth of muscle fibers. But the drug has not yet been shown to improve patients’ mobility or health. The FDA is requiring Sarepta to conduct followup studies on those measures for both drugs. If the company fails to show the drugs help patients, the FDA can withdraw approval—though it rarely does so.

The follow-up study for Vyondys is due by 2024. The drug will cost $300,000 per year for the typical patient—a child weighing 44 pounds, the company said. That’s the same price as Sarepta’s earlier drug.

Analysts said the unexpected decision could bode well for other experimental drugs with questionable study results, including a closely watched drug Alzheimer’s drug that will soon come before the agency.

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Things you should never buy from a thrift store

Thrift stores can be a bargain-hunter’s paradise, especially when budgets are tight. Where else can you stock up on furnishings, household goods, and clothing for just a tiny fraction of the original price? Not to mention, they make a great place to ditch last year’s fashion faux pas. As every smart thrift shopper knows, though, not everything that’s for sale is going to be worth purchasing, no matter how low its price may be. 

Money Talks News interviewed a number of frugality bloggers and other consumer advocates to determine which items should never be purchased secondhand. Many of these non-recommended items fell under three main categories: appliances and electronics, bedding, and baby items.

Avoid thrift store electronics and appliances

Small electronic items such as computer monitors may (or may not) have been checked to determine whether they’ll power on when plugged in, but that doesn’t mean they’re problem-free. Any thrift store electronics may have frayed cords or internal wiring issues which could lead to poor performance at best, or a genuine safety hazard at worst. Appliances could also have similar issues, and there really isn’t any way of testing their performance to any extent before purchasing. Not to mention, all such items are likely to be out of warranty. Even if the items are relatively new, though, it may be hard to claim warranty protection without the original proof of (first-time) purchase, and what thrift store donor is thoughtfully going to include all of the necessary paperwork along with the donated item?

Don't buy bedding or mattresses from secondhand sellers

This one should be a no-brainer. Anything people have been sleeping on, or in, could be a source of bedbugs or lice. Sure, people are supposed to clean their items before donating them, and a thrift store may reject items that are obviously soiled, but there’s no guarantee that seemingly clean sheets will have been thoroughly sanitized after use.

Mattresses are particularly icky in that they really can’t be adequately cleaned at all. Buying someone else’s mattress means that, even if you get lucky and escape insect infestation, you’ll still be sleeping on their old skin cells, dirt, and other unnamed ickiness.

Ban thrift store baby gear from your nursery

Used cribs? No, no, no, no. Older ones may not meet modern (post-2011) safety standards, and even newer ones may have been subject to product recalls. Used car seats are also a must not buy, as any car seat that has been in an accident (and how would you know whether it has or hasn’t?) is no longer considered safe. In addition, a used car seat, like a crib, may not live up to current safety guidelines, and some of its straps and connectors may have degraded and no longer function as they must. Even used toys are to be avoided, as they could be soiled or have missing or broken parts that could render them unsafe for a child. In fact, there’s a chance that thrift store toys, too, may have been recalled for posing a danger to kids.

Thrift stores may be a great place to buy cute, barely worn outfits for your rapidly growing bundle o’ joy, but when it comes to where your child sleeps or rides, or what they’re going to be snuggling or chewing on, you may be better off sticking to good old Walmart.

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Entrectinib effective, well-tolerated against ROS1 and NTRK lung cancers, especially with brain metastases

Pooled analysis of three phase 1 and 2 clinical trials published online ahead of print in the journal Lancet Oncology show that the drug entrectinib is effective and well-tolerated against advanced ROS1 and NTRK fusion-positive non-small cell lung cancers (NSCLC). Results of the trials STARTRK-1 (NCT02097810), STARTRK-2 (NCT02568267), and ALKA, show 77 percent response rate to entrectinib in 53 patients with ROS1+ NSCLC, with a median progression-free survival of 19 months and a median duration of response of 24.6 months. In 54 patients with NTRK+ NSCLC, 57 percent responded to entrectinib, with a median progression-free survival of 11.2 months and a median duration of response of 10.4 months. Based on the early promise of these trials, in August 2019 the U.S. Food and Drug Administration granted entrectinib accelerated approval for the treatment of metastatic ROS1+ NSCLC and for advanced tumors across cancer types defined by NTRK fusion. The current journal articles update these findings that led to approval.

“For a drug to get simultaneous approval for use against two different targets is somewhat unique. I don’t know of this ever happening before,” says Robert C. Doebele, MD, Ph.D., director of the University of Colorado Cancer Center Thoracic Oncology Research Initiative, senior author on the ROS1 study, and first author on the NTRK study.

About 2 percent of lung cancers are driven by the improper fusion of the gene ROS1 with one of a handful of possible genetic partners, resulting in a cancer-causing ROS1 fusion gene. About 1 percent of all solid tumors, including but not limited to lung cancers, are similarly caused by NTRK fusion genes. The FDA-approved drug crizotinib can silence the action of ROS1 fusion genes in some cases, but can’t reach cancers that have metastasized to the brain. And, unfortunately, 36 percent of patients with ROS1+ NSCLC already have brain metastases at the time of advanced disease diagnosis, and many more will go on to develop brain metastases during the course of care.

“For ROS1+ lung cancer, entrectinib represents a new and better standard of care due to entrectinib’s effectiveness against ROS1 in the body and especially due to its activity against ROS1+ brain metastases,” Doebele says. “For NTRK cancers, the picture is a little more complex and I think it depends on an NTRK+ cancer’s chance of developing brain metastases. Personally, if I were a patient and felt there was any chance of me getting brain mets, I would want this brain-penetrating drug.”

Included in these phase 1 or 2 studies were adults with locally advanced or metastatic ROS1+ or NTRK+ NSCLC who had received previous treatment not including other ROS1 inhibitors. Patients received entrectinib at a dose of at least 600 mg orally once per day, with at least 12 months follow-up. Doebele describes the drug as “well tolerated with a manageable safety profile,” with side effects including weight increase (8%) and neutropenia (4%). Eleven percent of patients had serious treatment-related adverse events, the most common of which were nervous system disorders (3%) and cardiac disorders (2%). No treatment-related deaths occurred.

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Michael Buble health latest: Singer on his son’s life-changing health battle – the latest

Michael Buble, 44, revived the appeal of classic American crooner music, with modern-day audiences lapping up his soulful jazz sound. The singer has also become a fixture at Christmas time, with his festive covers playing throughout December. The crooner may bring festive joy to people around the world, but he has been through some dark times too – his Son Noah was three-years-old when he was diagnosed with liver cancer in 2016.

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The singer’s son has since made a recovery but the experience has left Michael with an enlightened perspective on life.

Speaking to USA TODAY, he said: “I don’t even think about my career,” he said and that now, spending time with his family comes first, with everything else ranking “zero on the scale of (expletive) to care about.”

He continued: “It’s going to sound sloppy, but I remember sitting there and thinking, ‘Why the (expletive) am I worried about all this (expletive)? That’s what I was worried about? What people thought of me, or the numbers of something? That’s (expletive). That doesn’t matter.”

The star added: “It allows you to enjoy the little things in life and not be so (expletive) busy worrying how many likes you got, or how much money you made, stuff that makes you go, ‘Oh God, what was I thinking about?’”

According to the NHS, liver cancer is an uncommon but serious type of cancer that begins in the liver.

Your survival when diagnosed with cancer that started in the liver depends on how advanced it is at diagnosis and many other factors, such as your individual condition, type of liver cancer, treatment and level of fitness, explains Cancer Research UK.

Liver cancer symptoms

Symptoms of liver cancer are often vague and do not appear until the cancer is at an advanced stage.

According to the NHS, advanced symptoms can include:

  • Unintentional weight loss
  • Loss of appetite
  • Feeling very full after eating, even if the meal was small
  • Feeling and being sick
  • Pain or swelling in your abdomen (tummy)
  • Jaundice (yellowing of your skin and the whites of your eyes)
  • Itchy skin
  • Feeling very tired and weak

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How to live longer: Following this diet once a month could increase your life expectancy [TIPS]

 

Visit your GP if you notice any of the symptoms listed above – they’re more likely to be the result of a more common condition, such as an infection, but it’s best to have them checked, advises the NHS.

You should also contact your GP if you’ve previously been diagnosed with a condition known to affect the liver, such as cirrhosis or hepatitis C infection, and your health suddenly gets worse, notes the health body.

Who is at risk?

According to Cancer Research UK, there are some lifestyle factors that are known to increase your risk of developing liver cancer.

Heavy alcohol consumption, for example, can increase your risk of developing the deadly disease.

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As the charity explained: “Drinking alcohol long term can cause cirrhosis of the liver, which increases the risk of liver cancer. Alcohol might also directly damage the DNA inside liver cells.”

Cirrhosis is scarring of the liver caused by long-term liver damage, which prevents tissue the liver from working properly.

In addition, obesity has also been associated with liver cancer risk.

Diabetes and non alcoholic fatty liver disease – both risk factors for the disease – are more common in people who are overweight, so this may partly explain the link, explains Cancer Research UK.

How to treat it

The treatment for liver cancer depends on the stage of the condition. Treatment can include surgery and medicine.

As NHS explains, these are teams of specialists that work together to make decisions about the best way to proceed with your treatment.

Deciding which treatment is best for you can often be confusing.

Your cancer team will recommend what they think is the best treatment option, but the final decision will be yours.

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